Lewy body

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Contents

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Broader Terms

inclusion body

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Related Terms

neural degeneration

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Scope Note

filamentous cytoplasmic inclusions of unknown pathogenesis in some brain areas; found in association with several disabling and dementing neurodegenerative disorders.

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Facts (generated by robot; please edit if you find it inaccurate)

  • It’s unknown, at this time, if the Lewy body is part of the process killing the cell.
  • Dementia with Lewy-Body is the second most frequent cause of dementia in elderly adults.
  • The Lewy body is a distinctive neuronal inclusion that is always found in the substantia nigra and other specific brain regions in Parkinson's disease.
  • The Lewy body is an intraneuronal inclusion body that is one of the histologic hallmarks of Parkinson's disease, a degenerative disease of the brain.
  • 8 Generally, the Lewy body is thought to be the result of altered neurofilament metabolism and/or transport due to neuronal damage and subsequent degeneration, causing an accumulation of altered cytoskeletal elements.
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