Lysine analog

Use

When the microorganisms having a resistance to lysine analog is used, we define the microorganisms for the present invention as a strain which can grow and form colonies on a minimal medium supplemented with 2.
Preferably the internallysine or lysine analog is positioned between the T-helper epitope and the Bcell epitope or within the T- helper epitope.
The lysine analog is such one which inhibits proliferation of bacteria belonging to the genus Escherichia, but the suppression is entirely or partially desensitized if L-lysine co-exists in a medium.
The lysine analog L-oxalysine is an inhibitor of RNA synthesis.
Mechanism underlying cytotoxicity of thialysine, lysine analog, toward human acute leukemia Jurkat T cells.
In the invention there may preferably be employed microorganisms which further have the character of lacking threonine aldolase and/or the character of having resistance to lysine analog.
Neither system was strongly inhibited by d-lysine or the lysine analog S-2-aminoethyl-l-cysteine.
Similarly, plants transformed with a chimeric gene encoding a bacterial dihydrodipicolinate synthase were selected for resistance to the toxic lysine analog S-aminoethyl L-cysteine.

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