Magainin

From Health Encyclopedia

Use

antibiotic, pore forming protein

Facts (generated by robot; please edit if you find it inaccurate)

• At low concentrations, magainin is absorbed parallel to the membrane surface.
• reflect[s] one of three possibilities: 1) stained magainin is located outside the cell; 2) stained magainin is bound to the plasma membrane (as suggested by the prior art, see above), or 3) stained magainin is located inside a cell.
• CD experiments reveal that the membrane-bound fraction of magainin is approximately 80% helical at 8 degrees C, decreasing to approximately 60% at 45 degrees C.
• On page 789 [Thermal unfolding and helix-coil theory] the authors study the helix-coil transition when magainin is bound to the SUVs.
• The mode of action of magainin is based on its ability to insert into lipid bilayers of membranes, thereby disrupting membrane integrity by form- ing ion channels.

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