Mannose 6 phosphate

Broader Terms

Here we report the purification of -glucuronidase from human spleen and demonstrate enzymatically that mannose 6-phosphate is released on acid hydrolysis of pure enzyme.
The glucose to mannose-6-phosphate conversion , involves the intermediary step of the conversion of fructose-6-phosphate to mannose -6-phosphate by the enzyme phosphomannose isomerase (PMI) The direct conversion of mannose to mannose-6-phosphate is activated by the enzyme phosphokinase (PK).
Mannose-6-phosphate is converted to fructose-6-phosphate, by the enzyme phosphomannose isomerase, and then enters the glycolytic pathway or is converted to glucose-6-phosphate by the gluconeogenic pathway of hepatocytes.
Our results indicate (i) that mannose-6-phosphate is recognised by the enzyme and can promote the hysteretic transition and (ii) that the transient phase is part of the catalytic mechanism itself.
Mannose 6-phosphate is an important recognition site involved in transport of newly synthesized lysosomal enzymes from the endoplasmic reticulum to lysosomes.

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