Mannosidase

From Health Encyclopedia

Contents 1 Used for 2 Broader Terms 3 Related Terms 4 Scope Note 5 Facts (generated by robot; please edit if you find it inaccurate)

Used for

alpha mannosidase, beta mannosidase, EC 3.2.1.24, EC 3.2.1.25, mannanase, mannase

Broader Terms

O glycosidase

Related Terms

mannosidosis

Scope Note

EC 3.2.1.24 and EC 3.2.1.25.

Facts (generated by robot; please edit if you find it inaccurate)

• The soluble form of rat liver alpha-mannosidase is immunologically related to the endoplasmic reticulum membrane alpha-mannosidase.
• Man9-mannosidase is expressed as a N-glycoprotein with a molecular mass of 73 kDa.
• The lysosomal alpha-mannosidase is a dimeric enzyme, with a broad specificity towards alpha-mannosidic linkages on substrates originating both from ER misfolded proteins as well as endocytosed proteins.
• The newly synthesized alpha-mannosidase is normally delivered to the vacuole and converted to the 73-kDa polypeptide even when the secretory pathway is blocked by a subset of sec mutations.
• We have demonstrated the presence of a gene family which encodes alpha-mannosidases involved in processing of N-linked oligosaccharides.
• 24 Alpha-mannosidase.
• Substrate specificity engineering of beta-mannosidase and beta-glucosidase from Pyrococcus by exchange of unique active site residues.
• Alpha-mannosidase treatment of NK cells does not inhibit NK cell lytic function.
• 1107/S1744309105042508 ] c2d Crystallization and preliminary X-ray analysis of cytosolic -mannosidase from Thermotoga maritimaM.

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