Maytansine

From Health Encyclopedia

Use

antineoplastic antibiotic, macrolide antibiotic

Facts (generated by robot; please edit if you find it inaccurate)

• Maytansine is an experimental antitumor agent that has shown minimal efficacy against breast cancer with minimal myelosuppression in phase I trials.
• Thus, despite the fact that its resemblance to maytansine is small, rhizoxin appears to interact with tubulin in very much the same way as does maytansine.
• The results of this study indicate that maytansine is a very potent mitotic inhibitor and that it has no effect on macromolecular synthesis.
• Preliminary studies with the antitumor drugs colchicine, podophyllotoxin, paclitaxel, vinblastine, and maytansine, show that maytansine is the most potent, followed by paclitaxel and podophyllotoxin.
• [3] Maytansine is an alkaloid isolated from various species of the genus Maytenus, spiny shrubs that grow in many parts of Africa.

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