Melittin

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Contents

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Broader Terms

insect poison

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Related Terms

pore forming protein

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Scope Note

amphiphilic, helical peptide from bee venom which forms ionophoric channels in cell membranes; also binds and inhibits calmodulin and gastric H/K ATPase; intraventricular injection produces experimental hypertension.

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Facts (generated by robot; please edit if you find it inaccurate)

  • The use of melittin is one method used to impose the struc- ture on lipid systems.
  • Melittin is known to have cytolytic and voltage-gated ion conductivities.
  • For DMPC bilayers, melittin is found to decrease their fluidity only at their melting transition temperature.
  • Membrane fusion activity of succinylated melittin is triggered by protonation of its carboxyl groups.
  • Bee venom melittin is a potent toxin for reducing the threshold for calcium-induced calcium release in human and equine skeletal muscle.
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