Membrane attack complex

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The membrane attack complex is initiated when the complement protein, C5 converstase, cleaves C5 into C5a and C5b.
In a unique strain of PVG rats deficient in the C6 component of complement, the terminal membrane attack complex is not formed.
The membrane attack complex is formed in the following manner.
The membrane attack complex is also present in the walls of capillaries and perimysial vessels.
UniProt Knowledgebase keyword: Membrane attack complex DescriptionComponent of the membrane attack complex which groups the complement plasma glycoproteins C5b, C6, C7, C8 and polymeric C9 on biological membranes.
Selective blockade of membrane attack complex formation during simulated extracorporeal circulation inhibits platelet but not leukocyte activation.
A common final pathway is called the terminal pathway, or the membrane attack complex (MAC).
Membrane attack complex of complement and 20 kDa homologous restriction factor (CD59) in myocardial infarction.
2: Different activation pathways of the complement system (MBP: mannan-binding protein; MASP: MBP-associated serine protease; B: factor B; D: factor D; P: properdin; MAC: membrane attack complex) The components of the classical pathway are numbered 1 to 9 and prefixed by the letter C, e.

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