Molecular rearrangement
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- A solid state phase change is similar in that a molecular rearrangement is occurring, but the molecules remain closely packed so that the substance remains a solid.
- However, no molecular rearrangement is possible in this reaction indicating that no carbocation is produced.
- Such a molecular rearrangement is called a 1,2-hydride shift.
- " While the bcr-abl molecular rearrangement is always present in patients with CML, the Philadelphia chromosome may be absent (conventional cytogenetic analysis).
- The general applicability of this type of molecular rearrangement is necessarily limited because the strategic placement of two functional groups is required for successful implementation.
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