Monocyte chemoattractant protein 1
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attracts monocytes and memory T lymphocytes to the exclusion of other leukocytes such as neutrophils; it has been hypothesized that it plays a pathogenic role in a variety of diseases having a monocyte inflammatory component, such as atherosclerosis.
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Facts (generated by robot; please edit if you find it inaccurate)
- Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation.
- Monocyte chemoattractant protein-1 is a mediator of acute excitotoxic injury in neonatal rat brain.
- Monocyte chemoattractant protein-1 is excreted in excessive amounts in the urine of patients with lupus nephritis.
- fromJ Immunol -Sep 2001 -K A Carnevale Plasma monocyte chemoattractant protein 1 is a marker for joint inflammation in rheumatoid arthritis.
- (2001) 358 (737–745) (Printed in Great Britain) Multimerization of monocyte chemoattractant protein-1 is not required for glycosaminoglycan-dependent transendothelial chemotaxis Simi ALI, Adrian C.
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