Nephrogenic diabetes insipidus
From Health Encyclopedia
Contents |
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Used for
vasopressin resistant diabetes insipidus
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Broader Terms
diabetes insipidus, kidney disorder
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Related Terms
inborn renal tubular transport disorder
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Scope Note
polyuric disorder characterized by normal rates of renal filtration and solute excretion, but a persistent hypotonic urine due to the failure of renal tubules to respond to antidiuretic hormones, such as vasopressin, to reduce urine volume; tubular insensitivity to vasopressin can result from genetic defects, diseases, drug effects, or may occur with pregnancy.
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Facts (generated by robot; please edit if you find it inaccurate)
- In most cases, if nephrogenic diabetes insipidus is caused by medication (for example, lithium), stopping the medication leads to recovery of normal kidney function.
- When nephrogenic diabetes insipidus is hereditary, symptoms usually start soon after birth.
- The diagnosis of nephrogenic diabetes insipidus is made if, after the injection, the excessive urination continues, the urine remains dilute, and blood pressure and heart rate do not change.
- Related Collections Related Article Pathophysiology of Renal Disease and Progression Development of Lithium-Induced Nephrogenic Diabetes Insipidus Is Dissociated from Adenylyl Cyclase Activity Yuedan Li*, Stephen Shaw*, Erik-Jan Kamsteeg*, Alain Vandewalle, and Peter M.
- Nephrogenic diabetes insipidus is lack of response of the kidney to the fluid-conserving action of ADH.
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