Nucleobase analog

From Health Encyclopedia

Broader Terms

analog, antimetabolite

Narrower Terms

purine analog, pyrimidine analog

Facts (generated by robot; please edit if you find it inaccurate)

• The oligonucleotide analog of claim 1, wherein said nucleobase analog is selected from the group consisting of ##STR3## wherein Z is selected from the group consisting of H-- and CH.
• Perhaps the best known commercial nucleobase analog is 5-fluorouracil (5-FU) the structure of which is shown below: ##STR1## 5-FU is commercially available from Roche and is one of the most commonly used drugs for treating certain types of cancer.
• Use of the nucleobase analog deazaguanine (Z) with a PA linker results in a value of Get similar to that for oxidation of G by SA, whereas use of inosine (I) results in endergonic ET.
• Nucleoside and nucleobase analog mutagens.
• Use of the nucleobase analog deazaguanine (Z) with a PA linker results in a value of [Delta]Get similar to that for oxidation of G by SA, whereas use of inosine (I) results in endergonic ET.
• This heterocycle is of interest as a fluorescent nucleobase analog, but its hy- drogen-bonding properties are not preserved from the parent heterocycle, which limits its use (Fig.

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