Nucleoside phosphorylase

From Health Encyclopedia

Use

nucleoside ribosyltransferase

Facts (generated by robot; please edit if you find it inaccurate)

• Purine nucleoside phosphorylase is associated with centrioles and basal bodies.
• With the assumption that this commercial nucleoside phosphorylase is fully active, the kcat was then calculated as 33 [plus minus] 3 min[minus sign]1.
• The transition-state structure for purine nucleoside phosphorylase is characterized by (1) an elevated pKa at N7 of the purine ring for protonation or favorable H-bond interaction with the enzyme and (2) oxocarbenium ion formation in the ribosyl ring (Kline, P.
• Purine nucleoside phosphorylase is required for T-cell development while thymidine phosphorylase has been associated with angiogenesis.
• Under these conditions, 1 unit of nucleoside phosphorylase is defined as the amount of enzyme that causes an increase in absorbance of 0.

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