Nucleotide analog

From Health Encyclopedia

Broader Terms

analog

Narrower Terms

NAD(H) analog

Facts (generated by robot; please edit if you find it inaccurate)

• Each nucleotide analog is prepared as a triphosphate for incorporation into the RNA during DNA templated in vitro transcription.
• It is necessary that the experiment must be adjusted so that only 1 nucleotide analog is incorporated per 1 RNA molecule.
• This nucleotide analog is shown to be an excellent substrate for DNA polymerase Thermo Sequenase in DNA extension reactions.
• The fluorescence of this nucleotide analog is extremely sensitive to changes in nucleic acid structure and can serve as a sensitive reporter group to detect protein or small molecule binding to RNA.
• Indication Tenofovir disoproxil fumarate is the first nucleotide analog approved for HIV-1 treatment.
• of Molecular Biophysics and Biochemistry, Yale University Introduction Single-site nucleotide analog substitution has been a commonly used approach for gaining atomic resolution biochemical information about RNA function.
• Tenofovir DF: A Promising Nucleotide Analog in Development Bulletin of Experimental Treatments for AIDS, Spring, 2000 Nicholas Cheonis Tenofovir DF (TDF) is an experimental nucleotide reverse transcriptase inhibitor being developed by Gilead Sciences of Foster City, CA.
• HIV/AIDS Therapy Polyamide nucleotide analog blocks viral replication December 23rd, 2002 by Michael Greer, senior medical writer - Researchers in the United States have identified a novel agent that can virtually abolish HIV's replication capacity.
• HIV/AIDS Therapy: Polyamide nucleotide analog blocks viral replication AIDSWEEKLY Plus; Monday, December 23, 2002 Michael Greer, Senior Medical Writer NewsRx -- Researchers in the United States have identified a novel agent that can virtually abolish HIV's replication capacity.

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