Perforin
From Health Encyclopedia
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Use
cytolysin, pore forming protein
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Facts (generated by robot; please edit if you find it inaccurate)
- Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection.
- Perforin is a protein found within intracellular granules of NK and cytotoxic T cells and is a key factor in the lytic processes mediated by these cells.
- 7287 Figures and tables Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain RuthUellner, MarketaJ.
- 7287 Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain RuthUellner2, MarketaJ.
- Perforin is contained in the granules of cytotoxic T lymphocytes and its secretion contributes to T cell destruction of target cells.
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