Pernicious anemia

From Health Encyclopedia

Contents 1 See for 2 Broader Terms 3 Related Terms 4 Scope Note 5 Facts

See for

autoimmune gastrointestinal and liver disorder

Broader Terms

anemia

Related Terms

intrinsic factor

Scope Note

anemia due to poor intestinal absorption of vitamin B12 caused by defective production of intrinsic factor (a carrier protein) by the gastric mucosa.

Facts

• Pernicious anemia is a type of anemia in which the body does not absorb enough Vitamin B-12 from the digestive tract.
• Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to absorb vitamin B12 from the gastrointestinal tract.
• The term pernicious anemia is sometimes used more loosely to include non-autoimmune causes of vitamin B12 deficiency.
• Pernicious anemia is a type of megaloblastic anemia caused by an inability to absorb Vitamin B-12 due to a lack of intrinsic factor in gastric (stomach) secretions.
• Pernicious anemia is a form of the disease that is associated with an inability of the body to absorb vitamin B12.
• Pernicious anemia is often associated with an autoimmune-mediated attack of parietal cells of the stomach and/or intrinsic factor.
• Pernicious anemia a potentially dangerous form of anemia.

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