Plasma cell myeloma
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- P-glycoprotein expression in plasma-cell myeloma is associated with resistance to VAD.
- Plasma cell myeloma is a more complex neoplasm than suggested by the relative uniformity of its dominant plasma cells, which represent the terminal stage of normal B-cell differentiation.
- Plasma cell myeloma is either multifocal or widely disseminated in the marrow cavity and is often complicated by osteolytic lesions, pathologic fractures, hypercalcemia, anemia, and an aggressive clinical course.
- 1a0 Pathogenesis: The cause of plasma cell proliferation in plasma cell myeloma is unknown.
- Rundles Management of some diverse complications of plasma cell myeloma is reviewed with respect to prevention when possible and prompt treatment when necessary.
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