Pore forming protein

From Health Encyclopedia

Contents 1 Used for 2 See for 3 Broader Terms 4 Related Terms 5 Scope Note 6 Facts (generated by robot; please edit if you find it inaccurate)

Used for

aerolysin, cecropin, listeriolysin, magainin, perforin, Staphylococcus alpha toxin, Staphylococcus delta toxin

See for

porin, streptolysin

Broader Terms

protein

Related Terms

melittin

Scope Note

family of proteins used by lymphocytes and other cells to attack neighboring cells by forming pores in their outer membranes, leading to osmolysis; may be homologous to C9 complement.

Facts (generated by robot; please edit if you find it inaccurate)

• 267 EVIDENCE THAT Leishmania amazonensis PORE-FORMING PROTEIN IS LOCALIZED INSIDE MEMBRANOUS VESICLES BUT IS NOT SECRETED BY PROMASTIGOTES Noronha, F.
• Furthermore, theactivity of the pore-forming protein is optimally expressed at pH 5.
• It is especially interesting that the pore-forming protein is essentially identical to a pore-forming protein of human T lymphocytes.
• Since protein geometry and physiochemical characteristics are genetically determined, the pore-forming protein is able to form nanopores having a predetermined geometry.
• In preferred embodiments, the mutation in the pore-forming protein is a missense mutation or a deletion, is genetically engineered, and reduces the toxic response to a pore-forming toxin.

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