Receptor downregulation

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receptor expression

Facts (generated by robot; please edit if you find it inaccurate)

• EGF receptor downregulation is impaired in mutant receptors compared with wild-type EGF receptor.
• Myocardial beta-adrenergic receptor downregulation is likely to be partially responsible for the reduced chronotropic and inotropic responses to peak exercise in patients with mild to moderate symptomatic heart failure due to idiopathic dilated cardiomyopathy.
• The present study provides the most direct evidence to date that AT1 receptor downregulation is at least partially dependent on G protein (Gq) coupling.
• Central beta-adrenergic receptor downregulation is a robust and reversible neurochemical finding in animals after a course of electroconvulsive stimulation (ECS) or antidepressant drug administration.
• Receptor downregulation is also cell specific and involves the complex interaction between multiple cellular events to influence receptor expression.

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