Receptor upregulation

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receptor expression

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• Proteomics HGF receptor upregulation is a significant factor in angiogenic promotion August 11th, 2003 HGF receptor up-regulation is a significant factor in angiogenic promotion.
• These data indicate that receptor upregulation is directly related to increases in morphine potency.
• However, the mechanism for chronic tolerance is unclear because a direct relationship between tolerance and receptor upregulation is not consistently observed.
• The mechanism by which chronic nicotine exposure leads to receptor upregulation is not known.
• We assume that the maintenance of brief or repetitive input signals at membrane receptors necessary to achieve lasting receptor upregulation is mainly supported by the interac- tive dynamics of the intracellular system, rather than being located in individual switches.

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