Second messenger
From Health Encyclopedia
Contents |
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Broader Terms
biological signal transduction
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Related Terms
arachidonate, calcium, cyclic AMP, cyclic GMP, diacylglycerol, inositol phosphate
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Scope Note
diverse family of low molecular weight compounds such as cyclic AMP and calcium ions which transmit the biological signals initiated by receptor-ligand binding at the cell surface to intracellular targets such as gene expression.
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Facts (generated by robot; please edit if you find it inaccurate)
- What do you expect a dose-response curve to look like if a second messenger mediates the response? If you assume that the production of second messenger is proportional to receptor occupancy, the graph of agonist concentration vs.
- During the first stimulus, "postB" is at rest and little second messenger is formed.
- In another collaborative project, research using more specific inhibitors of the suspected second messenger is needed.
- This dependency of Ca2+ mobilization on single and double pulses can be simulated by a model in which a second messenger is produced in a voltage-dependent manner.
- Second messenger A second messenger is an intracellular metabolite or ion increasing or decreasing as a response to the stimulation of receptors by agonists, considered as the "first messenger".
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