Steroid hormone metabolism

From Health Encyclopedia

Broader Terms

hormone metabolism, steroid metabolism

Narrower Terms

steroid hormone biosynthesis

Facts (generated by robot; please edit if you find it inaccurate)

• Evidence for a role of megalin in steroid hormone metabolism is substantial.
• The complex nature of steroid hormone metabolism is made clearer to gain a comprehensive picture of the patient's full hormonal picture, providing a foundation upon which specific diagnosis and rapid treatment can be made.
• The current knowledge on the mechanisms of action of PCBs and dioxins and their metabolites, such as hydroxylated PCBs, on prenatal steroid hormone metabolism is still limited.
• Hepatic CPR-null mice developed normally and were able to breed, indicating that hepatic microsomal P450-mediated steroid hormone metabolism is not essential for fertility, demonstrating that a major evolutionary role for hepatic P450s is to protect mammals from their environment.
• Brief Project Description: Exposure to exogenous sex steroid agonists, antagonists, or modulators of endogenous sex steroid hormone metabolism is known to alter normal sexual dimorphic development and lead to defeminization/ masculinization of females and demasculinization/ feminization of males.

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