Th2 cell

See

helper T lymphocyte

Facts (generated by robot; please edit if you find it inaccurate)

• Introduction Top Introduction Materials and Methods Results Discussion References The CD4+ Th2 cell is a critical mediators of the asthma phenotype.
• However, the most important factor that determines whether a nave CD4 + T cell diVerentiates into a Th1 or a Th2 cell is the presence of a speciWc cytokine within the microenvironment in which the nave T cell is activated.
• It appears from these data that the Th1 cell is down regulated following exposure to UVB irradiation although the effect on the Th2 cell is not yet clearly defined.
• One difficulty in performing this research is that the Th2 cell is very rare (less than 1% of T cells) and induces asthma symptoms very rapidly, making it extremely difficult to study and measure.
• It has been postulated that the Th1 cell is the "inducer" of a DTH response since it secretes interferon gamma (IFN ), a potent stimulator of macrophages, while the Th2 cell is either not involved or acting as a downregulator of the cell mediated immune response.