Transamination
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Facts (generated by robot; please edit if you find it inaccurate)
- Transamination is a major pathway of L-dopa metabolism following peripheral decarboxylase inhibition.
- Ethylamine transamination is inhibited 4-fold by Al(3+) metalation, while alanine transamination is inhibited only 1.
- Using the more labile isobutyryl (iBu) protecting group, the level of transamination is much reduced at around 4%.
- INTRODUCTION Decarboxylation-dependent transamination is considered to be an inactivating side reaction catalysed by many amino acid a-decarboxylases.
- There is evidence that transamination is rate limiting in the catabolism of BCAAs in rat liver, where BCAT activity is low.
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