Transcarboxylase

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Use

carboxyltransferase /carbamoyltransferase

Facts (generated by robot; please edit if you find it inaccurate)

  • Biotin-dependent carboxylation catalyzed by transcarboxylase is a stepwise process.
  • Transcarboxylase is made up of a central hexameric subunit (S20,W similar 12 S), three peripheral dimeric metallo subunits (S20,W similar to 5 S), and six biotinyl carboxyl carrier subunits (S20,W similar to 1.
  • Transcarboxylase is a well-characterized enzyme composed of 30 polypeptides of three different types: twelve 1.
  • Thus, transcarboxylase is made up of 18 peptides, 6 metals, and 6 biotins.
  • Radioactivity of 60Co-labeled transcarboxylase is primarily associated with a subunit of the enzyme with a sedimentation constant of 6S that contains little or no biotin.

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