Transin
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- The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.
- Transin is a neutral metalloproteinase initially isolated from malignantly transformed rat fibroblasts and subsequently shown to be homologous to human stromelysin.
- The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.
- Transin is a transformation-associated gene which is expressed constitutively in rat fibroblasts transformed by a variety of oncogenes and in malignant mouse skin carcinomas but not benign papillomas or normal skin.
- Transin is overexpresse 1000 d in metastatic tumor cell lines as compared to non-metastatic tumors (Korczak et al, 1991).
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