Transition mutation
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- Our data indicate that the CpG dinucleotide targeted by the transition mutation is stably methylated in CHO cell chromosomes.
- In the haplogroup 8 chromosomes, a T -> C transition mutation is homogenized throughout MSY1 arrays, with the exception of one or two repeats at the 3' ends of alleles, but without eliminating the pre-existing type 1, 3 and 4 repeats.
- A T/A G/C transition mutation is the second most common type (38%) of ENU-induced mutations.
- Upon replication, an A=T transition mutation is fixed and inherited by Joe.
- This transition mutation is predicted to result in a proline-to-leucine substitution at residue 251 of AGT1.
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