Transpeptidation
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Facts (generated by robot; please edit if you find it inaccurate)
- Evidence that transpeptidation is a significant function of gamma-glutamyl transpeptidase.
- Because proteolysis is slower in D2O but transpeptidation is faster, the isotopically sensitive step must occur after release of both products of proteolysis, which precludes putative acyl-enzyme covalent intermediates.
- Transpeptidation is inhibited by pencillin at concentrations that inhibit hydrolysis (carboxypeptidase action) of the donor peptide.
- Transpeptidation is favoured both by increasing the pH and by dec 5a8 reasing the water content of the reaction mixtures.
- Transpeptidation is favoured both by increasing the pH and by decreasing the water content of the reaction mixtures.
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