alisun
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Joined: 05 Jun 2002
Posts: 274
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 Posted: 12/15/05 - 06:07 Post subject: |
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Hello! There are many synonyms for this disease. They are: Refractory anaemia, Refractory anaemia with ring sideroblasts, Refractory anaemia with excess blasts, Refractory anaemia with excess blasts in transformation, and Chronic myelomonocytic leukaemia, which is a distinct sub-type. The myelodysplastic syndromes (MDS) is a group of diseases in which the production of blood cells by the bone marrow is disrupted. This disease may affect all types of blood cells. It may happen that some of the patients with MDS develop acute leukaemia but most of them do not. If it does develop, it, it is acute myeloid leukaemia1, which is more difficult to treat than primary acute myeloid leukaemia. The bone marrow in myelodysplastic syndrome is typically more active than normal and yet the numbers of blood cells in the circulation are reduced. This is because most of the cells being produced in the bone marrow are defective and are destroyed before they leave the bone marrow to enter the blood stream. The hallmark of the myelodysplastic syndromes is the combination of a hyperactive marrow with low blood cell counts. A reduction in numbers of all types of blood cell is called pancytopaenia.
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