Couldn't find what you looking for?

TRY OUR SEARCH!

I have been prescribed with diphenhydramine for my troubles with sleeping. I was taking it 50 mg every six hours. But what has happened? I have missed the dose and I took two at once. I know that I should not do that and I don't know what I was thinking about while taking it but it has happened. I am afraid of overdose. How much of diphenhydramine is an overdose?

Loading...

No one can claim how much is enough for overdose. Every man reacts differently on each medication and the time and strength of reaction varies. Doubling the dose is not smart thing to do but it happens. Other most common reason of overdose is taking two similar medications or taking diphenhydramine orally and topically for instance. You could report what you have done to your doctor or to wait for the signs of overdose. Symptoms may include hallucinations, loss of consciousness, seizures, tremor and weakness.
Reply

Loading...

although I'm usually reluctant to challenge to expert opinion of an online MD.. who I'm sure is well versed in every aspect of pharmachemistry, i do feel compelled to put your serious overdose risk in proportionate perspective. let me assure you, as a person who frequently takes 4 capsules of 50mg diphenhydramine, being the active ingredient in benadryl, which comes in 25mg capsules which would be like taking 8 benadryls, as does my mother, and my partner, and none of us in the hundreds of times taking that large of a dose, has ever had any remote adverse effects. I'm not suggesting that the average person exceed the recommended dose to the extent that we do, I'm simply attempting to put a relatively benign substance in perspective. however the point made about the variance in body chemistry is something to consider and while the average person would probably find it difficult to overdose on benadryl, someone with a less common body chemistry could possible have a serious reaction to just one benadryl, but if your that certain type, chances are, by the time you reached adulthood you would have already somehow found that out. so basically, if taking one didnt send you into anaphylactic shock, then 2 or 3 probably wouldn't hurt you either.
Reply

Loading...

to Guest who feels its "benign" to take so much of that stuff.. my sister, an otherwise very healthy 38 year old, suddenly died and we had no idea why or how until the autopsy came back. She'd simply taken too much benadryl! That stuff can KILL YOU. Stop taking so much please, as it DOES build up in your gallbladder and other organs and can cause harm. My sister left behind a husband and two small boys, over some stupid over the counter benadryl!
Reply

Loading...

Overdose from 100mg is highly unlikely. in fact, 50-100mg is the standard dose in other countries such as the UK.
however, to the person taking the equivalent of 8 benadryl at once, know that diphenhydramine citrate is a drug for which most people build tolerance. your reaction now that you have the drug built up in your system is very different from the reaction someone who rarely takes the drug would have. personally, 50mg puts me to sleep in less than 30 minutes, and 100mg can make my heart race while also putting me to sleep for at least 12 hours. it is very uncomfortable. I imagine 200mg would cause more serious side-effects, but i am not going to test the theory.
Reply

Loading...

I do not sleep very well at all... i get around 3 to 4 hrs of sleep, after a while, that is not good. i can not aford to go to doctors, so I take diphenhydramine to help me sleep, i take 50mg tablets, 1 did not do anything for me, nither did 2, 3 of them i could call a sleep in 3 hrs or so, 4 of them. within 2hrs i can sleep. that is 200mg. and i can sleep for 6 to 9 hrs.
Reply

Loading...

Unfortunately, I found out the hard way what OD on benadryl is like. I was taking consecutive doses that were more than the recommended dose, because I have never had a bad experience and the heaviness and sleepiness were the desired effects. This stuff does cause full blown delirium. Pupils dilate. Within a 2 day period I consumed an entire bottle of 100 25mg capsules. The last of the bottle causes full blown hallucinations. I was having conversations with friends and family that were not there. I would zone out during a conversation with my mom, for example (we do not live in the same city) and go to look for her only to realize that she had never been there. Later the same evening I ended up venturing out on foot, with only my t-shirt and underwear on to catch up with friends walking down the street (there were no people out at 10:30 pm, much less friends who are not locales). I left my home entirely unlocked, wandered across a major highway, and found myself talking to someone who turned before my very eyes into a tree (which is what I was actually talking to). I put myself in harms way, and ended up being returned safely to my home by a local friendly police officer. I sought out the officer, because upon returning to my home by myself I found an intruder in my home going through my belongings. There was no intruder, but I fled because the hallucinations are life-like and for all sensable perceptions real to the person experiencing them. I only found out the next day that this is indeed a symtom of benadryl OD, and it is due to the strong anti-cholergic effect of this class of antihistamine. Dramamine is also another, weaker, type in this class. The phenomenon is anticholergic delirium, and because of the heart complications and likelihood of acting on a seemingly real hallucination (visual), very dangerous. The next day I did some research and found that people actually take too much benadryl for "recreational trips"! You can read more about this on erwoid.org. As for me, it was simply a mistake. I was trying to sedate myself because I was depressed and trying to escape anxiety by sleeping more than I naturally do. While that is stupid, the lesson is important and interesting. Most of these recreational users take anywhere from 10-40 25mg pills in one dose, so the likelihood of lethal dose is extremely minimal. Anti-cholergics like benadryl are especially potent to geriatric patients (the elderly). I am 33 and a female weighing 155 lbs.
Reply

Loading...

As a psychiatrist, I can tell you that 100mgs of Diphenhydramine HCL is NOT an overdose. 100mgs is the maxium dose in a twenty-four hour period. At 100mgs, you would just experience fatigue, nausea, and dizziness.
Reply

Loading...

a little background
my names adam
im 15 years old
male
6 feet tall
160 pounds


Alright basically.
on 8 different occasions
I have taken 20-30 benadryl 25mg tabs
at once to trip
because it does cause quite a bit of hallucinations
Talking to people who aren't there
thinking you are holding things
thinking you're in a different place
and all that
its also extremely hard to think about anything
and when you try to talk
you usually forget what you were talking about
half way through a sentence
movement is also quite difficult
almost like being drunk without
the drunk part
basically EVERYTHING you do
becomes a task
and a very difficult one at that
your mouth also gets EXTREMELY dry
basically
we'd just stock up on shitloads of water
cause you have to be drinking it ALOT.
we will never touch the stuff ever again
last time
A friend of mine went to the hospital
after tripping three nights in a row
and what we found out was that
the ingredient
Diphenydramine
no matter how much taken
That specific ingredient will not cause hallucinations
every time we did it
we were merely overdosing on the drug
it wasn't making us trip
we were just ODing
All of us are extremely lucky to be alive
and are never going to take it again
Because it's christmas ever right now
my friend and her brother are stuck at the hospital
and they may go into foster care.
Reply

Loading...

Someone I know just took a full bottle of 100, leaving a few and was rushed to the ER... had a stroke in the ambulance, and they said it looked like she was going to die.

Right now, she's relatively stable but they were concerned about lack of oxygen and brain damage.
Reply

Loading...

I just got out of the hospital last week for what I'm told was an accidental Benadryl overdose.

I'm a 220 lb male. I've been taking 3 benadryls most every night for some months now (as a sleeping aid)

* I "passed-out cold" 3 times one morning last week. I was rushed to the hospital where I underwent numerous cardio testing over a span of 3 days. "Nothing" was found.

Finally, my own account of my Benadryl intake was siezed-upon as the explanation for the "siezures". I haven't seen any toxicology reports -- but that would sew-it-up nicely huh?

So, I'm either pretty stupid -- or this thing isn't really over yet. We'll see.
Reply

Loading...

Quote:

I just got out of the hospital last week for what I'm told was an accidental Benadryl overdose.



There is practically 0 chance that a 220 lb male overdosed on 75mg of benadryl, especially having been taking it routinely. personally I have taken doses of up to 300mg as a sleep aid and have both read of and witnessed doses of upwards of 1500mg. Of course, 1500mg is not by any means recommended and probably potentially fatal, but typically when someone has an emergency trip to a hospital due to diphenhydramine, it's from their incoherent speech that makes them appear in danger. In reality, it is a fairly powerful psychadelic that creates profoundly realistic hallucinations.

Understandably, many people are worried when they see a friend or child speaking incoherently to a person who isn't there and call for help.

Doses of up to 100mg should be perfectly safe for all people, and I suspect (my non-doctor non-pharmacist's opinion) that it would take 300-500mg or more before you should feel in danger.

Of course, everyone's personal health situation is different and any illnesses you may have can drastically change your response to all drugs. Particular care should be taken if mixing diphenhydramine with other drugs, especally painkillers such as opiates, alcohol, or benzodiazapines (valium and other sedatives)


Conclusion: A typical healthy person probably has nothing to worry about from less than 1mg per pound of body weight. For reference, the LD50 (dose at which 50% of animal test subjects died) for lab rats is 500mg per 1kg of body weight. If a similar relationship is true for humans, a 60Kg person would require 30,000mg to die from this.

I wouldn't be concerned with less than 300mg unless you have health problems or are mixing with other sedatives or alcohol.

best wishes
Reply

Loading...

a few years ago i tried to commit suicide. i overdosed on tylenol pms. 25,000mg of tylenol and 1,250 mg of benadryl. wow. i fortunately got medical treatment or i would have died. but, i am completely healthy and perfect in every way. wow, that benadryl sure made for a huge trip. it lasted really bad for 24 hours, but hung around, making me hallucinate randomly for a total of 4 days. i was in a coma for short while and i cant remember every hallucination, but they were definitely crazy hallucinations. id be in a room talking to someone then id be in the desert with some indians at a bbq. weird sh*t.

female, 103 pounds, 5'2, age 21 at OD.
Reply

Loading...

I took 48, 25 mg pills once. My breathing got to 5 breaths a minute, I had to be intubated to protect my airway. I woke up about 12 hours later. I have had no residual effects. If I hadn't been found, I would have died from that much.
Reply

Loading...

iv been alittle worried about an overdose but im sure that alot of people will agree that its not really all that easy to just stop taking sleeping pills. especially if u have been takin big quantities. iv been taking about 11 50mg pills anight for about 9 months. but iv developed a bad habit of waking on my days off of work and taking more during the day and im not really sure why cause i dont really fall asleep from them anymore.every time i run out i tell ymself im not gonna take anymore than i always find my self standing in line at wallgreens with a box in my hand. ywice a week. so like i said naturally i am worried about an overdose but what im really concerned with it my inability to stop taking cause im sure at the rate im taking them and the amount i take an overdose in evitable. so im really looking for advice on how i need to go about stopping taking them more than im worried about how much i gotta take before an overdose. any advice will help
Reply

Loading...