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Hi. My sister (26 yo) was diagnosed with antiphospholipid syndrome (at first, she was diagnosed with lupus?!). I have read that this is an autoimmune disorder of unknown cause, characterized by recurrent venous or arterial thrombosis, but would like to know more about some treatment options. Is APS a deadly disease?

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Hi. You got confused. There are multiple terms for antiphospholipid syndrome, such as lupus anticoagulant. It is very misleading because it doesn`t mean that a patient have systemic lupus erythematosus. Catastrophic APS is a serious and often fatal condition - mortality rate 50%. It is characterized by multiorgan infarctions. Generally, treatment regimens for APS must be individualized. About the treatment options, there is a prophylactic therapy, which eliminates some risk factors, such as smoking or hypertension. For catastrophic APS patients a treatment with intensive anticoagulation and plasmapheresis seems to be beneficial. Corticosteroids, cyclophosphamide, and intravenous immunoglobulin may be used.
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