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Researchers have found that the presence of endometriosis, which affects 10% of all reproductive women in the United States, can result in a 60% increase of coronary heart disease in these patients.
Researchers have found that the presence of endometriosis, which affects 10% of all reproductive women in the United States, can result in a 60% increase of coronary heart disease in these patients. It was reported that there were 65 cases of heart disease per 100,000 patients with endometriosis as compared to 19 cases in women without the disease. It was also found that the association between this condition and heart disease was highest in women under 40 years of age.

This equates to a three-fold increase of having coronary heart disease related conditions such as chest pain or heart attacks which may require treatment such as stenting or bypass of any blocked arteries. 

Treatment of endometriosis, which may entail surgical removal of the ovaries, will result in menopause which in itself can also increase the risk of coronary heart disease by 40%. Other possible causes for the increased risk of coronary heart disease in patients with endometriosis can include increased cholesterol levels, chronic inflammation and increased oxidative stress which results in the exposure to free radicals. These conditions are often associated with patients diagnosed with endometriosis.

Management of endometriosis

The treatment of endometriosis can include oral medications for pain relief and hormonal regulation in order to control the symptoms. Surgical procedures can also be performed if the endometriosis is complicated or not controlling on the oral medication. The prevention or management of heart disease is also very important here.

Oral medication

  • Pain medication - these can include paracetamol, ibuprofen, naproxen and sometimes even opioids.
  • Hormone therapy - hormonal contraceptives (birth control pills, patches or vaginal rings) help to control the hormones responsible for the accumulation of endometrial tissue. Gonadotropin-releasing hormone (Gn-RH) agonists and antagonists and agonists cause estrogen levels to decrease and this leads to prevention of menstruation. Meproxyprogesterone can also stop menstruation from occurring and reduces the growth of abnormal endometrial tissue. Danazol suppresses the growth of endometrial tissue but it may not be the first choice drug since it can cause serious side-effects.

Surgery

  • Conservative surgery - this is a laparoscopic procedure where as much of the abnormally deposited endometrial tissue is removed. 
  • Hysterectomy - complete removal of the uterus and cervix is considered to be done as a last resort procedure which will only be performed in severe cases. The ovaries can also be removed (oophorectomy) in order to reduce the estrogen levels and therefore stop stimulation of the endometrial tissue. 

Other treatments

In-vitro fertilization can be considered as an alternative to conservative surgery, especially for women who are still looking to conceive or if conservative surgery hasn't been effective.  

Seeing that endometriosis, and the associated conditions which are linked to it, can increase the risk of developing coronary heart disease, it's important for doctors to prevent coronary heart disease, manage any existing heart related issues or treat any underlying conditions. Cholesterol levels need to be checked and treated with statins if they are elevated, elevated blood pressure needs to be controlled with anti-hypertensive medications and low-dose aspirin therapy may also need to be initiated.

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