I am 53 and have been post menopausal for almost 4 years now. Had a cortisone epidural just yesterday in my lumbar area and am spotting today. Pretty shocked!!! Calling the doc where I had the injection but there possible side effects did state change I menstrual flow, of course I have not had one for years. I do need to state that I have had many cortisone injections in my back, shoulders and knees before. Never had bleeding as a side effect.