Specific Drug Interactions And Contraindications Regarding ARV Use

ATV +/− RTV or COBI

• Cardiac medications - ranolazine and dronedarone.
• Statins - lovastatin and simvastatin.
• Tuberculosis medications - rifampin and rifapentine.
• Neurological agents - midazolam, lurasidone, pimozide, triazolam.
• Herbs - St. John's wort.
• Hepatitis C (HCV) drugs - boceprevir and simeprevir.
• Others - alfuzosin, cisapride, irinotecan, salmeterol, ergot derivatives and sildenafil.

DRV/r or DRV/c

• Cardiac medications - dronedarone and ranolazine.
• Statins - lovastatin and simvastatin.
• Tuberculosis medications - rifampin and rifapentine.
• Neurological agents - lurasidone, midazolam, pimozide, triazolam.
• Herbs - St. John's wort.
• HCV drugs - dasabuvir, boceprevir, paritaprevir, ombitasvir and simeprevir
• Others - alfuzosin, cisapride,salmeterol, sildenafil and ergot derivatives.

FPV +/− RTV

• Cardiac medications - flecainide, dronedarone, ranolazine and propafenone.
• Statins - lovastatin and simvastatin.
• Tuberculosis medications - rifampin and rifapentine.
• Neurological agents - midazolam, lurasidone, pimozide, triazolam.
• Herbs - St. John's wort.
• HCV drugs - dasabuvir, boceprevir, paritaprevir, ombitasvir and simeprevir.
• Others - alfuzosin, cisapride, salmeterol, sildenafil and ergot derivatives.

LPV/r

• Cardiac medications - dronedarone and ranolazine.
• Statins - lovastatin and simvastatin.
• Tuberculosis medications - rifampin and rifapentine.
• Neurological agents - pimozide, lurasidone, midazolam, triazolam.
• Herbs - St. John's wort.
• HCV drugs - dasabuvir, boceprevir, ombitasvir, paritaprevir and simeprevir.
• Others - alfuzosin, cisapride,salmeterol, ergot derivatives and sildenafil.

SQV/r

• Cardiac medications - amiodarone, flecainide, dofetilide, dronedarone, lidocaine, propafenone, quinidine, ranolazine.
• Statins - lovastatin and simvastatin.
• Tuberculosis medications - rifampin and rifapentine.
• Neurological agents - midazolam, lurasidone, pimozide, trazodone, triazolam.
• Herbs - St. John's wort and garlic supplements.
• HCV drugs - boceprevir, dasabuvir, ombitasvir, paritaprevir and simeprevir.
• Others - alfuzosin, cisapride,salmeterol, ergot derivatives and sildenafil.

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TPV/r

• Cardiac medications - dronedarone, amiodarone, flecainide, quinidine,  propafenone and ranolazine.
• Statins - lovastatin and simvastatin.
• Tuberculosis medications - rifampin and rifapentine.
• Neurological agents - midazolam, lurasidone, pimozide and triazolam.
• Herbs - St. John's wort and garlic supplements.
• HCV drugs -  ledipasvir, boceprevir, dasabuvir,, ombitasvir, paritaprevir, simeprevir and sofosbuvir.
• Others - alfuzosin, cisapride,salmeterol, ergot derivatives and sildenafil.

EFV

• Tuberculosis medication - rifapentine.
• Herbs - St. John's wort.
• HCV drugs - boceprevir, dasabuvir, ombitasvir, paritaprevir and simeprevir.

ETR

• Tuberculosis medication - rifampin, rifapentine.
• Antiepileptic medication - carbamazepine, Phenobarbital and phenytoin.
• Herbs - St. John's wort.
• HCV drugs - ombitasvir, dasabuvir, paritaprevir and simeprevir.
• Antiplatelet medication - clopidogrel.

NVP

• Tuberculosis medication - rifapentine.
• Herbs - St. John's wort.
• HCV drugs - dasabuvir, ombitasvir, paritaprevir and simeprevir.
• Antifungal agent - ketoconazole.

RPV

• Tuberculosis medication - rifampin, rifapentine.
• Antiepileptic medication - oxcarbazepine, carbamazepine, phenobarbital and phenytoin.
• Herbs - St. John's wort.
• HCV drugs - dasabuvir, ombitasvir and paritaprevir.
• Anti-gastric acid medication - proton pump inhibitors.

MVC

• Tuberculosis medication - rifapentine.
• Herbs - St. John's wort.
• HCV drugs - dasabuvir, ombitasvir and paritaprevir.

DTG

• Cardiac agents - dofetilide.
• Tuberculosis medication - rifapentine.
• Herbs - St. John's wort.

EVG/c/TDF/ FTC or EVG + PI/r combinations

• Cardiac medications - ranolazine.
• Statins - lovastatin and simvastatin.
• Tuberculosis medications - rifampin and rifapentine.
• Neurological agents - lurasidone, midazolam, pimozide, triazolam.
• Herbs - St. John's wort.
• HCV drugs - boceprevir, dasabuvir, ombitasvir, paritaprevir and simeprevir for EVG + PI/r. The aforementioned including ledipasvir are contraindicated for EVG/c/TDF/ FTC.
• Others - alfuzosin, cisapride, ergot derivatives,salmeterol and sildenafil.