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An American friend of mine who is not all that old (I think he's sixty) recently got out of the hospital after a bout with sepsis. An all too frequent cause of death in the elderly, sepsis occurs when bacteria from an infected wound find their way into the bloodstream. My friend had a little blister on his toe that turned first gray and then black and blue. It began to smell terrible, so he threw out his socks and tried to "dry it out" by going barefoot inside the house. Then he noticed his foot seemed irritated. One evening the redness and heat spread all the way up to his knee, and the next morning he was too sick even to get out of bed to call for help. When he got to the emergency room the next day, the doctors quickly told him that he had sepsis, and he was given an IV antibiotic called Zosyn and admitted into the hospital.
The infection left his bloodstream in just hours, and the redness and oozing on his leg resolved a few days later. Within a few days, he was out of the hospital and on his way home. A few days later, he was with his wife and feeling, what is the word Americans use, frisky, so he popped a Viagra in preparation for the evening's celebration.
Four hour later he was in the emergency room yet again, this time with a condition called priapism. He had actually had the erection that lasts more than four hours that the instructions for the use of the drug warn about. The doctor had to, how to put this, stick a needle in his erection to remove blood to stop the painful condition. Ironically, the doctor then applied an antibiotic.
Antibiotics And Antifungals Affect Liver Enzymes
Erythromycin (no longer widely used),
Sulfamethoxazole (which is included in Bactrim).