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WHAT ARE THE SIDE EFFECTS OF DISCONTINUING COPAXIN?

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Copaxone is synthetic protein; it is non-interferon drug that is used in treatment of MS. It works by resembling myelin and decreases body’s attack on myelin. Copaxone has shown as very effective in preventing relapses in RRMS. It is disease modifying drug, an immunomodulator. It is polymer of 4 amino acids: glutamic acid, alanine, lysine and tyrosine, which are naturally occurring.
When therapy is discontinued, occurrence of side effects depends on titer of neutralizing antibodies in blood. There may be no side effects at all, and at the other side, exacerbations may happen if antibodies were present when therapy was discontinued. As drug by itself does not cause serious side effects during therapy, discontinuing is related to reactivation of the symptoms of MS. Side effects of copaxone include nausea, irritation at the place of injection, muscle stiffness and joint pain.
It is not evidenced that copaxone causes dependence or abuse so there can not be withdrawal symptoms.
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