What are side effects when using a combination of Wellbutrin with a high blood pressure medication?

Combining multiple medications, especially those affecting mood and mental health like lithium, Wellbutrin, and Invega Sustenna, can have complex interactions and potential side effects. Adding high blood pressure medication to the mix can further complicate the situation. Here are some considerations:

Lithium: Lithium is commonly used to treat bipolar disorder. It can have side effects like tremors, increased thirst or urination, weight gain, and kidney function changes. Lithium levels in the blood need to be carefully monitored as too high levels can be toxic.
Wellbutrin (Bupropion): Wellbutrin is often prescribed for depression and can increase alertness and energy. Common side effects include insomnia, dry mouth, and, in some cases, an increase in blood pressure.
Invega Sustenna (Paliperidone): Invega Sustenna is an antipsychotic medication used to treat schizophrenia. Side effects can include weight gain, metabolic changes, and movement disorders.
High Blood Pressure Medication: The specific medication used to treat high blood pressure will vary, but some common classes of medications include beta-blockers, ACE inhibitors, diuretics, and calcium channel blockers. These medications can have their own set of side effects, which can vary depending on the specific drug.

When combining these medications with high blood pressure medication, potential interactions and side effects to watch for include:

Increased Blood Pressure: Some medications used to treat psychiatric conditions can affect blood pressure. The combination with high blood pressure medication may require careful monitoring and dose adjustments.
Kidney Function: Both lithium and some high blood pressure medications can affect kidney function. Regular kidney function tests are typically necessary.
Metabolic Effects: Some psychiatric medications, including atypical antipsychotics like Invega, can contribute to weight gain and metabolic changes. High blood pressure medications may need to be carefully selected to minimize these effects.
Neurological Effects: Combining these medications can increase the risk of neurological side effects such as tremors or movement disorders.