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When taking blood pressure meds, it is advised to cease consuming grapefruit or grapefruit juice, as there might be some negative effects to that.

Normally, consuming grapefruit is good for the body, as this fruit is rich in vitamins and helps fortify the immune system. It contains both vitamin C and potassium, which are great for your body functions. However, grapefruit has been known to interact with different types of medication, but not in the way that you would expect.

Grapefruit and the human body

What grapefruit juice actually does is intensify the effect of the medication you are taking. This poses a risk as doctors give out specific daily doses so that your medication can interact positively with your system. When a drug is present in the body in a quantity higher than the recommended dose, it also causes more intense side effects.

Our bodies produce an enzyme which is called CYP3A4, located in the small intestine. This enzyme causes the body to break down medication that you’re taking. When consuming grapefruit or its juice, it blocks the CYP3A4 enzyme from acting accordingly, causing a lower metabolization of the drugs. Consequently, that drug will stay in your body for longer.

Doctors have revealed the fact that every person has a different quantity of CYP3A4 in their bodies, so the effects of grapefruit juice will also vary from one person to another. There have been a lot of studies conducted on the interaction between grapefruit and medicine. While the fruit causes some drugs to stay in the body for a longer period of time, it has an opposite effect on some other drugs.

For instance, if you’re taking medication with fexofenadine, grapefruit juice will prevent the required amount of drug from entering the blood, thus minimizing its efficiency. This happens because grapefruit juice can also interfere with drug transporters, which are proteins that help our bodies absorb the drugs by moving them to the cells.

Grapefruit and medication

Grapefruit doesn’t interact with just every type of medication out there. However, the FDA has required that medical companies specify any potential interactions on their labels, especially for over the counter drugs.

Some of the following drugs are known for their grapefruit juice interaction:

  • Those for abnormal heart treatment.
  • Anti-anxiety medication.
  • Drug to prevent organ rejection after a transplant.
  • Corticosteroids that are prescribed to treat ulcerative colitis or Crohn’s disease.
  • Calcium channel blockers or angiotensin inhibitors which are used as high blood pressure treatment.
  • Antihistamines.
  • Medication prescribed to lower cholesterol levels.

Medication for lowering blood pressure

When you have been diagnosed with hypertension is a very advances stage, or when lifestyle changes aren’t enough to keep your blood pressure under control, doctors will prescribe one or more medications for high blood pressure, depending on the exact problems that need to be solved.

Some of the most common blood pressure meds include:

  • Calcium channel blockers, from preventing calcium buildup in the heart and artery cells.
  • Renin inhibitors, which are meant to block the production of renin (a kidney enzyme that is linked to an increase in blood pressure).
  • ACE inhibitors, pills that cause the blood vessels to relax and prevent the release of angiotensin (a hormone that is known for narrowing blood vessels and preventing blood from circulating normally).
  • Beta blockers, which block the effects of epinephrine (adrenaline), causing the heart to beat at a slower rate.
  • Angiotensin II receptor blockers which, unlike ACE inhibitors, don’t prevent angiotensin formation, but rather block it from acting upon the blood vessels by narrowing them.
  • Diuretics, which are often referred to as water pills, and remove excess sodium and water from your organism, as fluid build-up is a threat to your blood pressure.
  • Aldosterone antagonists, which prevent a hormone called norepinephrine from narrowing your arteries.
  • Central-acting agents that act on your brain to make sure that it doesn’t tell your heart to beat faster.
  • Vasodilators that, such as the name hints, will cause your blood vessels to dilated, facilitating blood flow.

Grapefruit and high blood pressure meds

Generally speaking, a lot of high blood pressure medications do not interact with grapefruit juice. The ones that do are based on felodipine, nifedipine, losartan, and eplerenone. The first two are channel blockers, while the other two work to counteract angiotensin effects.

As far as the calcium channel blockers are concerned, these meds are prescribed to high blood pressure patients that need to have their arteries muscles relaxed, as constriction of these vessels prevents blood from circulating normally. Calcium channel blockers are among the most frequently-prescribed hypertension drugs.

Losartan and eplerenone are prescribed for patients that have too much angiotensin in their bodies, causing high blood pressure. Losartan interacts with grapefruit juice in a sense that the latter prevents the drug from reaching the bloodstream, thus diminishing its effects and rendering it useless.

On the other hand, eplerenone levels will greatly increase when it interacts with grapefruit juice. It causes your potassium levels to rise as well, thus interfering with your heart’s rhythm. Alternatively, doctors may choose to prescribe spironolactone, which is a drug that acts similarly to eplerenone and losartan, without any grapefruit juice interactions.

As far as calcium channel blockers are concerned, an alternative is amlodipine, which is just as efficient as felodipine and nifedipine, but without grapefruit juice interactions.


One of the lifestyle changes recommended by doctors is to eat healthy food that increases your potassium levels, and grapefruit is very rich in potassium, making it a wise dietary choice. If you like to consume grapefruit or its juice, but you have been prescribed a medicine that interacts with it, consult with your doctor to see if they can prescribe a safer alternative. Of this is not possible, you do need to stay away from grapefruit.

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