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I want to know what causes schwann cell to become tumor. I read somewhere about condition which can be transmitted from generation to generation known as type II neurofibromatosis. Here individuals are born with one defective tumor suppressor gene and they need only one mutation in any schwann cell during their lifetime to cause development of a tumor. In addition to bilateral acoustic neuromas these patients can have schwanomas of other cranial nerves.

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The answer to question what causes a schwann cell to become a tumor remains unclear. There appear to be two regions not only one within the genetic makeup of a schwann cell termed tumor suppressor genes. The main function of these genes is to prevent the formation of tumors. Only one properly functioning gene is needed to prevent a tumor from occurring therefore a change or a mutation has to occur in the same schwann cell twice thereby affecting both tumor suppressor genes before a tumor can form.
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