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What is Lo/Ovral-28 and how does it work?

Lo/Ovral-28 is the commercial name of a contraceptive drug. There are other drugs available in the market with different commercial names but with the same combination that works in exactly the same manner.

There are two active hormones in this drug, Ethinyl estradiol and norgestrel. These two hormones prevent conception by preventing the normal ovulation in females, cause certain changes in the uterine and cervix lining, and make the vaginal fluid thicker as well.

This means that the sperm has a much lesser chance of reaching the cervix even in the off-chance that ovulation has taken place in the presence of these drugs as well. Even if an egg does get fertilized, then it too would most likely be passed out of the body since it would not attach to the uterus.

Side Effects of Lo/Ovral-28

Like all hormonal contraceptive drugs, Lo/Ovral-28 also comes with some side effects that patients should be aware of.

Patients may experience some amount of nausea, vomiting, swelling in the feet, fluid retention, weight changes, tenderness in the breasts, headaches, and some vaginal spotting during the first few months of use.

These side effects are considered minor and come with the territory. Among them, patients can get the most concerned about gaining weight. It is not a given that women who take drugs will gain weight for sure. Along with fluid retention, some patients also experience a change in their appetites. Some women eat lesser while others start to eat more than usual.

In a much smaller subset of people, some more serious side effects will be seen like an increase in blood pressure, mood swings, a sudden increase in vaginal bleeding, or a change in the color of the urine. These side effects must be reported to your doctor and appropriate care will be taken. The decision to add another drug to take care of the problem or to change the drug altogether will be taken by the doctor but a lot of the times these side effects are considered serious enough to cease the use of the drug altogether.

Some even rarer side effects could be seen in people who have an allergic reaction to the drug. These reactions are considered as medical emergencies and immediate medical attention must be sought out if they are observed.

A difficulty in breathing, swelling of the throat, tongue, the sudden appearance of rashes o the body, dizziness, and even a loss of consciousness.

As mentioned earlier, these symptoms are considered extremely rare, however, the potential for allergic reactions does exist with hormonal contraceptives.


There is no drug which regulates the hormonal functioning of your body that is free from side effects. The choice that patients have to make is to weigh the potential side effects against the benefits that they are deriving.  Talking to your doctor about any specific questions or concerns that you might have is highly recommended. Patients should also know that stopping and starting these drugs on their own without consulting a doctor is potentially dangerous and can cause some serious, long=term, harm.  

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