I was on depo for 4 months. Only 1 set of shots. I gained 65 pounds in that amount of time. I can not loose it!! I hate my body now and I went straight to the implant. It seems like I can't shake off the weight at all. I was 110 before the shot. Now I'm almost 175-180 pounds. I went from a size 4 to a size 15-16. Depression and panic attacks happened alot more often.