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I found this forum searching for fatigue related to ESI... I had my 3rd ESI 3 weeks ago and am feeling fatigue in the afternoons, I cannot hardly function without resting for an hour or so. This has never happened to me before, I have always had tons of energy, and the ESI is the only change to my routine. Prayers for all of you,,, that we would all be healed from this fatigue!
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I had an injection 4 wks ago for nerve root compression and the fatigue and nausea is unbelievable. I am usually very active even at over seventy years of age but since the injection have felt so very weak that I was beginning to wonder if there was was something else wrong until I read the posts on this site. I am so very sorry to read of the problems with everyone but feel comforted to know that other people have experienced similar problems and that we are not all building things up out of proportion. I trust the weakness and fatigue will ease quickly for us all and will keep praying!!
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Thanks everyone for sharing this all makes sense now. For me it was about 3 weeks after my epidural for a herniated disc that I began to show all the signs of CFS. Exhaustion, Foggy memory, sore throat followed by a slight cough, headache (mostly left side behind the eye). I can't be 100% certain the two or linked but I'd say very likely.
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Below in this message is the post posted 5 months ago here.

I just want to say that It has been quite a while ago that I was able to get past the fatigue I first experienced after having an epidural cortisone shot.

If it were not for the epidural cortisone shot I was given, I would be stuck in my recliner. I could not walk more than a couple of feet without pain in my hip, due to sciatica that was in my lower back, but showed up in my hip as pain. Now I can go shopping all I want, clean house, garden and etc.,....as long as I don't over do it.

So hopefully, the tiredness that some of you are feeling after your procedure will pass soon, and you will get your life back. So hang in there! It does take time.

God bless
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Guest 5 months ago

I just had an epidural cortisone shot a week ago for a pinched nerve in the lower spine. Now I don't have the energy to enjoy the wonderful affect of the shot. I was never told of the possibility of continued fatigue after the procedure.

I can only be up and about for a few minutes at a time, because I feel as though I am going to fall over if I don't sit down. I have never, ever, had this problem before the epidural.

I hope there is some sort of a solution to this problem we are all having....and the sooner the better.

I am glad I came across this website and to know that others have had the same experience with fatigue. I plan on trying some of the suggestions I have read here. Thank you all for sharing.
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Thanks for sharing. I had an Epi Shot for back nerve pain a week ago and since i felt exhausted with mild headache and fuzziness. Good to know i am not the only one. Strange that the doc and nurse don't know about this side affect. Maybe its not that common overall? Anyway hope it wears off soon.
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I'm sorry to read that so many lives have been affected by this. Are we just the tip of the iceberg? In my last post I said I thought somehow the injected cortisone disrupted the body's own cortisol production, because reduced cortisol (hypocortisolism) is associated with CF. I have now found an article which states that little has been written about the possible side effects of administering steroids into the epidural space, and explains how the steroids then spread through the circulatory system, affecting all the tissues of the body, before being eliminated by the liver.

Moreover, it also says that the injected cortisone does indeed interfer with the body's cortisol production :
''Synthetic glucocorticoids have higher receptor binding affinities for the glucocorticoid receptor and alter endogenous cortisol function by taking over the hypothalamic–pituitary–adrenal (HPA) axis. ''
I wonder if our cortisol production only recovers very slowly from being zapped by the injected synthetic steroids? Hence we have the symptoms of reduced cortisol levels - fuzzy brain, low energy, sleep disturbance, reduced immune response, inflammation. Why is there so little research being carried out into the side effects of epidural cortisone?
I hope some of you are already beginning to see improvements. Have faith because it really does get better and better with time.

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I had a epidural cortisone shot about 3 months ago, after 3 days I woke up one morning and had thrush. I had white dots all done my throat and tongue, I had almost no voice. My doctor said it was a yeast infection. Later that week I noticed by stomach was so extended I thought I would have stretch marks, Bloating and gas. I was also experiencing fatigue. I have narcolepsy so I/m already taking adderall, but they weren't even helping. I went back to the doctor and he took a closer look at all my symptoms and realized I had suppression of adrenal glands, he told me I would have these symptoms until all of the cortisone was out of my systems and my adrenal glands would have to figure out on their own how to start working again. My Doctor said this same thing had happened to him years ago and it took almost a year to completely recover. I also gained about 15 lbs, less than 2 weeks after my injection.
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I have had tiredness for many many years now. I'm currently having vitb12 injections monthly and I had KENACORT A 10 injection 2 months ago to see if it helps my CFS. I also dosed up daily on olive leaf and spirilina. I felt NORMAL again 4 a couple of months and now I'm back to feeling extremely low and no energy again. I'm due for another KENACORT. Now after reading the previous messages I'm not so sure.
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I received 2 spinal injections, a spinal block and a cortisone shot at L4-5 and S-1. This was on Dec. 1. 2016. It is now 2 months later, and l have severe ringing in both ears, severe lethargy, no energy, iffy appetite, etc. , and it's gething worse. Feels similar to supressed adrenals. My pain doc said to get a hearing test and testosterode check due to my age (60). This is BS. Though l had a herniated disc, the pain was manageable with oral meds. I now regret getting the epidural and l'm going to call my primary doc today.
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I have had injections for 2 years after the last 6 months I have been very tired I go again in 7 days ! Stopped pain meds over a year ago besides tramadol I don't know if it is the injections or the meds but I want some answers on my next visit!! Not ready for surgery because I suffer in to many areas!!
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Same here ...Since my Bronchitis got treated with Cortisnine I have cronique fatigue and my life is not a life anymore :-( How to get out of this ??? All doctors tell me everything is ok with me but I know I am not !
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I have the same chronic tiredness as the others Why?
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same tiredness aathe others Why/
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same above with the other request
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chorinic tiredness after cortisone injections
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