DEPO SHOT-birthcontrol- WEIGHT LOSS So all the forums and articles I've came across say the depo is effective.BUT you will GAIN weight. Well I was 230 when I started (I have always been over weight, my life.) My body produces me insulin than i take in. I HAVE NEVER LOST WEIGHT IN MY ENTIRE LIFE. I've always played some type of sport , some type of activity. I started the depo late January, it is now late March, I will need it again April, I weigh 200 now. I'm appalled at the fact I actually lost weight, plus a birth control that my bestfriend gained 50 pounds on. any comments?