I gained 30lbs in a year when starting prozac (133 to 163!!!), I eat very clean, workout 5 times a week and couldn't lose even a pound for the life of me. I went to my doctor and she told me it was the prozac and tried to give me dieting tips and had all my bloodwork checked lol what a joke, I stopped prozac and I would say after about 3-5 weeks all of the prozac left my system. Since it left my system I continued to diet and workout, it has now been 2 weeks after it has been out of my system and I have lost 10 lbs already! (163-153!) The weight is practically falling off. Doctor tried to tell me it wasn't the prozac that made me gain weight AND keep it on...man was she wrong... Stay positive, I know first hand how frustrating it is to work so hard and see no results, medicine affects everyone differently but with me prozac totally destroyed my imagine and self confidence, I now feel better than ever and am getting back to were I want to be!!!! :D