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I've been on Depo for almost two years (November will be two years) and I've never had spotting or a period since I started it. I'm 23 years old. I started spotting and cramping last Tuesday and it started as just a little bit of brown just when I wiped after going pee, and today it got worse. I have to wear pads now, it's gotten so bad, and my cramps are getting worse. And today was Thursday. So it's been going on over a week now. Two nights ago I also noticed my nipples are leaking a milky discharge (white and a little sticky) and if I squeeze them, more comes out. I went to the health department today for my depo shot, and asked for a pregnancy test and it came back negative, but they couldn't give me a reason for my symptoms. Could I still be pregnant? If this helps, I'm also on Zoloft for anxiety, Metoprolol for heart rate, Aciphex for heart burn and Albuterol for asthma. And in case you were wondering, yes I have had unprotected sex with my fiancé...

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You should go to the hospital and ask for a blood test to see for sure. 
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