I have been on Effexor for almost 8 months now, and have put on 18 pounds since then. I have never been thin but I've never been the weight I'm at right now...I feel awful. My doc says Effexor doesn't cause weight gain but I think it's BS, it has to be.... I'm heavier now than after just having my baby (when I started taking it). When I forget to take the pill, my body reminds me within a few hours of the hour I was supposed to take it... I get nausea and overall the feeling you get when you are preggo and having morning sickness...I dread having to get off it because of how I'll feel and because it has worked beautifully for my depression, but I just can't handle more weight. My appointment is in 3 weeks but quite frankly, I'm calling my doc tomorrow to find a solution...I just hope if I manage to get off it eventually, that my weight will start coming off as well.