Hi, I started having the DPU symptoms when I was about 17 years old, i have always been and still am a very active person. The DPU is a crippling disease at times. I would go backpacking in the mountains, shoulders would swell so bad that I looked like Dwayne Johnson, THE ROCK. I'd go hunting and walk 4-5 miles, the next day my right foot would swell so bad that I truly feared that the skin was going to break open. I would limp around until the swelling on my right foot would subside, only to have my left foot swell terribly bad immediately after. It would itch, but I can't scratch it cuz it will double in size within hours. I ride dirt bikes often, swollen lumps would appear on my rear end from the seat. I would scratch an itch on my forehead during the night while sleeping. Wake up with a red swollen lump on my forehead. I put up with this garbage daily from the time I was 18 til around 28yrs old. Then it stopped. Hallelujah. It was GONE for about 3 years on its own as far as I can tell. No treatments worked. I gave up after years of doctors and specialists, thousands and thousands of dollars spent on the different antihistamines, copays, time lost for nothing. Never had a diagnosis. Never had a reason why or a cause. I'm now 36 yrs old. I am a mechanic by trade and I have arthritis from using my hands all day. I finally went to see an arthritis dr a few yrs ago, he was the first dr to say that it could be Delayed Pressure Urticaria. I had never heard that before. I just happened to be swollen at the time of my appointment, and since it was not an appointment for the swelling, I only mentioned it so that the dr didn't irritate it more. I searched DPU online as soon as I got home and I instantly knew that is what I have. I watched a video of a guy on YouTube too. I started Humira for the Rheumatoid arthritis and anklosing spondylitis maybe 3yrs ago. I have been on Humira injections once per week ever since that day. I have been able to keep the symptoms at bay for years now and since the medication lowers my immune system, when I get sick or an infection, i stop the Humira until its cleared up and I almost always get the swelling back within a week or two. I have taken many rounds of Doxycycline since the DPU started almost 20yrs ago and it has never helped with my DPU. If it helps some people, great. It just didn't help me. I swear by the Humira. It is very expensive and it doesn't help the rheumatoid arthritis much, but well worth it for the DPU!! I am only writing this to hopefully help someone else who has been plagued with DPU like I have been half my life now. I had all but given up on searching for a diagnosis and treatment. Even the steroids never helped me enough to make it worth taking, since the swelling went down after 24-48 hrs, it was hard to say whether it worked or not. I have not tried the gold bond that was mentioned, since mine seems to be under control now. I would recommend to anyone who has DPU to make an appointment with a PRIVATE PRACTICE Arthritis clinic for an evaluation and most likely, they will find a reason to put you on Humira. DPU MUST be an Autoimmune Disorder since the Humira deals with autoimmune disorders and it lowers the immune system. I have nothing to gain by posting my story. I truly believe in the Humira and I hope that I will help at least one person to relieve some DPU related symptoms. It is the only thing that has helped me. It is my miracle drug. It is possible to live with DPU but it's not fun. It has ruined my vacations, and forced me to cosider cost vs rewards of certain activities. Thanks for reading and I hope that i help someone else to live a full and happy life once again!!! Good luck. I hope that the other people who posted on here actually fixed it with the doxycycline and gold bond and that it just didn't go into the "remission" phase. I have read a few times that others have gone into a remission phase also for a couple years. I feel your pain.
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UPDATE. Hi, I have now been on the Rheumatoid Arthritis medication Humira for a few years. If this post helps ONE person get relief from DPU, I will be happy. I NEVER get the DPU symptoms while I am taking the Humira. It is expensive, but I was able to get assistance by signing up for it through the medicine company and I pay $5/shot. I have never written a comment about anything online ever, I felt like I had to comment after suffering from DPU for so many years. Never having a diagnosis. It is absolutely miserable, as anyone who has DPU can attest. IT IS TERRIBLE. I had no choice but to live with it for 20 yrs. It was just by dumb luck that I got the 1st real diagnosis. I searched it online and it was exactly right. I was happy, then bummed out that nobody had a cure. I read about the parasite theory early on in an article about a lady in Italy or something, but very shortly after I started the Humira and never pursued the parasite theory. The HUMIRA definitely works. Do or say anything you have to to get in to see a Arthritis Specialist and take the shot. I went to a small private practice Arthritis/Osteoporosis clinic, with my doctors referral, and my insurance covered the visit. It keeps the symptoms at bay. I had to share my story just in case someone else wants to make the DPU symptoms stop. I would not bother with the medicine for the RA except that it's working so great for the DPU. I take a shot weekly now. It lowers the immune system. I used to try explaining the DPU symptoms to doctors and I would always say that it's like an overactive immune system. So it makes complete sense that it works. PLEASE READ MY STORY. it's not a joke or me trying to promote anything. I could care less about the drug companies making a profit. I had to live with it too long. Spent a fortune on specialists and allergy drugs that never worked. That was always the first place the dr would send me. Allergist. It is Not allergies. I would scratch my forehead in the middle of the night and wake up with a welt. My left foot would swell on one day, then I was forced to put all my weight on my right foot, then it would swell. Typically the swelling lasted for about 2 days and got so bad that I seriously thought my skin would break open. I would have to crawl to the bathroom at times it got so bad. I got the hives on my rearend just from sitting in a classroom . I would hit my arm on something while working and get the large welt. I am a mechanic and small injuries are common, and so were the welts/hives. It could be a parasite, but at least for me, over the past 20 years it should have been eradicated with the medicines I've taken for other non-related problems. I would try to kill a parasite 1st since it may work for you and it's more of a one time fix. The Humira is a long term solution that doesn't stop. anyone who suffers from DPU like I did, will do or try anything. please read this and pay attention. It's all truth. I truly hope it helps people. I wouldn't wish this disease on my worst enemy. It is more like a curse! NOTHING ELSE EVER HELPED ME. I tried it all. Good luck.
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Ya'll try it.
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I finally was cured!
my DPU strated in 2010 up to the end of 2016 when I lately visited an indian Allregist Dr in Toledo Ohio and explain my case. his first question was "have you bittin by a tick in the past?" and my answer was YES! then he asked me to stop eating red meat for six months and that was the first RIGHT hint. then I did what he said and the DPU was Gone!
I 'm writting this to help poeple becuase I know how painful it is.
I wish this is the case for all of you.
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