I have been on 75 mg of Effexor for almost 2 years.  I feel wonderful - sometimes too wonderful!  The weight gain is horrible - I have gained 25 pounds total and feel like I gain weight daily.  I have done everything - exercise, counting calories, eating better than ever!  After consulting my doctor we are going to try to come off of the drug.  My main reason for taking it was menopausal.  I have been on a 37.5 mg does for 3 days and very few side effects.  Any idea if just the reduction in dose will get some weight loss started.  Just like other posters - the weight gain has made me more depressed than what I was initially going through!