I found this site/comments after I googled my symptons and was blown away. I took doxycycline for the 1st time this last Friday evening & woke w/a feeling that something was stuck in my chest...like the pill or something I ate didn't make it down. The pain wasn't unbearable but certainly discomforting when I would eat/drink. I spoke with my doctor this morning b/c the pain had worsen and she said that this is a side effect of this medicine and that it should be taken w/food. She suggested I take an over the counter drug called Prilosec and should feel relief w/in a week. I then can continue the medicine if I so choose but w/the largest meal of the day. I am relieved to know this is completely normal and I thank this forum as I would have stressed all weekend that something more critical was wrong. Not so sure my skin/blemishes are worth this feeling though.