My daughter was put on the Depo for regulation of her period at 15. We are now off this shot, one year later and 25 lbs gained. She's an avid athletes, playing soccer on 3 teams, thus training or playing 2-3 hours daily, year around. She's a very healthy eater, no sugar, sodas, fried foods, etc. They can't say this shot doesn't make you gain weight. With her being sporty she is very muscular. This gain is no means a lot muscle weight. Now, she is self conscious of herself, something she never was before. If we could turn back a year, I'd never allow this shot to be given!